Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems

Kentaro Iwasawa, Takanori Takebe, Keishi Kishimoto, Alice Sorel, Carlos Ferran-Heredia, Lu Han, Mitsuru Morimoto, James M. Wells, Aaron M. Zorn

Published: 2022-08-16 DOI: 10.1038/s41596-022-00733-3

tissue engineering

human pluripotent stem cells

organ-specific mesenchyme

mesoderm differentiation

signaling pathways

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Development of visceral organs such as the esophagus, lung, liver and stomach are coordinated by reciprocal signaling interactions between the endoderm and adjacent mesoderm cells in the fetal foregut. Although the recent successes in recapitulating devel
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ACKNOWLEDGMENTS

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Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems

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